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| Antigenic Specificity | CD279 |
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| Clone | 29F.1A12 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2a, κ |
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| Format | PE-Dazzle? 594 conjugate |
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| Size | 25 μg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PE/Dazzle? 594 anti-mouse CD279 (PD-1). CD279, also known as programmed death-1 (PD-1), is a 50-55 kD glycoprotein belonging to the CD28 family of the Ig superfamily. PD-1 is expressed on activated splenic T and B cells and thymocytes. It is induced on activated myeloid cells as well. PD-1 is involved in lymphocyte clonal selection and peripheral tolerance through binding its ligands, B7-H1 (PD-L1) and B7-DC (PD-L2). It has been reported that PD-1 and PD-L1 interactions are critical to positive selection and play a role in shaping the T cell repertoire. PD-L1 negative costimulation is essential for prolonged survival of intratesticular islet allografts. |
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| Immunogen | PD-1 cDNA followed by PD-1-Ig fusion protein |
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| Other Names | Programmed Death-1, PD1 |
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| Gene, Accession # | Gene ID: 18566 |
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| Catalog # | 135227 |
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| Price | |
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| Order / More Info | CD279 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 20453843 |
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