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產(chǎn)品名稱

Neurofilament H & M (NF-H/NF-M), Phospho Antibody from BIOLEGEND

產(chǎn)品貨號(hào)

835602

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

500 μl

產(chǎn)品品牌

BIOLEGEND

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Neurofilament H & M (NF-H/NF-M), Phospho
Clone	SMI 35
Host Species	Mouse
Reactive Species	human, mouse, rat
Isotype	IgG1, κ
Format	unconjugated
Size	500 μl
Concentration	n/a
Applications	IHC-P, Western Blot (WB), IHC-F, ELISA
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Anti-Neurofilament H & M (NF-H/NF-M), Hypophosphorylated. Neurofilaments (NFs) are approximately 10 nanometer intermediate filaments found in neurons. They are a major component of the neuronal cytoskeleton, and function primarily to provide structural support for the axon and to regulate the axon diameter. There are three major NF subunits, and the names given to these subunits are based upon the apparent molecular mass of the mammalian subunits on SDS-PAGE. The light or lowest neurofilament (NF-L) runs at 68-70 kD. The medium or middle (NF-M) runs at about 145-160 kD, and the heavy or highest (NF-H) runs at 200-220 kD. However, the actual molecular weight of these proteins is considerably lower due to the highly charged C-terminal regions of the molecules. The level of NF gene expression correlates with the axonal diameter, which controls how fast electrical signals travel down the axon. Mutant mice with NF abnormalities have phenotypes resembling amyotrophic lateral sclerosis. NF immunostaining is common in diagnostic neuropathology. It is useful for differentiating neurons (positive for NF) from the glia (negative for NF).
Immunogen	n/a
Other Names	Neurofilament heavy polypeptide, NF-H, 200 kDa neurofilament protein, neurofilament triplet H protein, SMI-35R-500
Gene, Accession #	Gene ID: 4744
Catalog #	835602
Price
Order / More Info	Neurofilament H & M (NF-H/NF-M), Phospho Antibody from BIOLEGEND
Product Specific References	PubMed: 21278408
產(chǎn)品資料

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