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| Antigenic Specificity | BACE1 |
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| Clone | A17035K |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | peroxidase (HRP) conjugate |
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| Size | 25 μg |
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| Concentration | n/a |
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| Applications | Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | HRP anti-BACE1. Beta-site APP-cleaving enzyme 1 (BACE1), also known as aspartyl protease 2 (ASP-2) and memapsin 2, is a type I transmembrane aspartic protease with 501 amino acid that is related to the pepsin family and the retroviral aspartic proteases. The BACE1 catalytic domain contains aspartic protease active site motifs at amino acids 93-96 and 289-292, with each motif containing the highly conserved sequence defining aspartic proteases, D(T/S)G(T/S). BACE1 is expressed at low levels in most cell types of the body, although it is more highly expressed in neurons. In the brain, the protein is highly expressed in the substantia nigra, locus coruleus, and medulla oblongata. It is localized within acidic intracellular compartments including endosomes and trans-Golgi network (TGN). In the brain, BACE1 is involved in proteolytic processing of the amyloid precursor protein (APP) which generates the b amyloid peptide- a peptide that is associated with Alzheimer's disease. BACE1 cleaves APP at the N-terminus of the b amyloid peptide sequence, between residues 671 and 672, which leads to extracellular release of b-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by g-secretase. The physiological function of BACE1 is not clearly understood, although it may modulate sodium currents by cleavage of voltage-gated Na channel accessory subunits (Navβ1-4). Also, BACE1 has been implicated in the regulation of myelination and myelin sheath thickness and in the control of motor coordination via cleavage of neuregulin-1 and neuregulin-3, and also in axon guidance via cleavage of close homolog of L1 (CHL1). |
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| Immunogen | Recombinant human BACE1 protein. |
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| Other Names | Beta-Secretase 1, Membrane-Associated Aspartic Protease 2, Beta-Site APP Cleaving Enzyme 1, Aspartyl Protease 2, Memapsin-2, Asp 2, BACE, ASP2, Beta-Site Amyloid Beta A4 Precursor Protein-Cleaving Enzyme, Beta-Site Amyloid Precursor Protein Cleaving Enzyme 1, Transmembrane Aspartic Proteinase Asp2, Beta-Secretase 1 Precursor Variant 1, Beta-Site APP-Cleaving Enzyme 1, APP Beta-Secretase |
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| Gene, Accession # | Gene ID: 23621 |
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| Catalog # | 852903 |
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| Price | |
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| Order / More Info | BACE1 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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