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產(chǎn)品名稱

LIN28B (internal region) Antibody from CREATIVE DIAGNOSTICS

產(chǎn)品貨號

CABT-BL2149

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

n/a

產(chǎn)品品牌

CREATIVE DIAGNOSTICS

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	LIN28B (internal region)
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	unconjugated
Size	n/a
Concentration	n/a
Applications	WB, IHC, ELISA, FC
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Rabbit Anti-Human LIN28B polyclonal antibody for WB, IHC, ELISA, FC. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Specifically recognizes the 5-GGAG-3 motif in the terminal loop of pre-let-7. Also recognizes and binds non pre-let-7 pre-miRNAs that contain the 5-GGAG-3 motif in the terminal loop, leading to their terminal uridylation and subsequent degradation. Mediates MYC-mediated let-7 repression. Isoform 1, when overexpressed, stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth.
Immunogen	Synthetic peptide
Other Names	n/a
Gene, Accession #	Gene ID: 389421, UniProt: Q6ZN17
Catalog #	CABT-BL2149
Price
Order / More Info	LIN28B (internal region) Antibody from CREATIVE DIAGNOSTICS
Product Specific References	n/a
產(chǎn)品資料

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