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產(chǎn)品名稱

Golimumab ELISA Assay Kit from EAGLE BIOSCIENCES INC.

產(chǎn)品貨號(hào)

IG-AA107

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

1 x 96 well

產(chǎn)品品牌

EAGLE BIOSCIENCES INC.

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Golimumab ELISA Assay Kit
Description	The ImmunoGuide Golimumab ELISA is a sandwich-type ELISA. Standards and diluted samples (serum or plasma) are incubated in the microtitre plate coated with recombinant human TNF-? (rh TNF-?). After incubation, the wells are washed. A horseradish peroxidase (HRP)-conjugated anti-human IgG monoclonal antibody is added and binds to the Fc part of Golimumab pre-captured by the rh TNF-? on the surface of the wells. Following incubation, the wells are washed and the bound enzymatic activity is detected by addition of chromogen-substrate. The colour developed is proportional to the amount of Golimumab in the standards or samples. Results of samples can be determined directly by using the standard curve. Sample Types: serum, plasma. Range: 6 - 200 ng/mL. Sensitivity: 5 ng/mL. Time: 2 hours ? Golimumab is a human monoclonal antibody that binds to both the soluble and transmembrane bioactive forms of human TNFα. This interaction prevents the binding of TNFα to its receptors, thereby inhibiting the biological activity of TNF. Golimumab has been proven effective in the treatment of Rheumatoid Arthritis (RA), Ankylosing Spondylitis (AS), Psoriatic Arthritis (PsA) or Ulcerative Colitis (UC). Antibodies to Golimumab were detected in 57 (4%) of Golimumab -treated patients across the Phase 3 RA, PsA, and AS trials through Week 24. Similar rates were observed in each of the three indications. Patients who received Golimumab with concomitant Methotrexate (MTX) had a lower proportion of antibodies to Golimumab than patients who received Golimumab without MTX (approximately 2% versus 7%, respectively). Of the patients with a positive antibody response to Golimumab in the Phase 2 and 3 trials, most were determined to have neutralizing antibodies to Golimumab as measured by a cell-based functional assay. The data from the literature demonstrated that Anti-Drug Antibody positivity was significantly associated with low Golimumab levels and poor therapeutic response. The positive correlation between serum drug trough levels and therapeutic response indicates that drug monitoring could be useful for optimising the dosing of biologics in a personalised therapy strategy.
Size	1 x 96 well
Concentration	n/a
Applications	RUO
Other Names	IG-AA107 anti-drug antibody kits, anti drug shikari shakari free ELISA Assay Kit EIA, Immunoassay, Golimumab
Gene, Accession, CAS #	n/a
Catalog #	IG-AA107
Price
Order / More Info	Golimumab ELISA Assay Kit from EAGLE BIOSCIENCES INC.
Product Specific References	n/a
產(chǎn)品資料

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