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產(chǎn)品名稱

SP-B, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HP9049

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	SP-B, Human
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human
Isotype	n/a
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, immunoassay, paraffin sections, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The polyclonal antibody recognizes the human surfactant protein B (SP-B). There are four surfactant-specific proteins, designated surfactant protein A (SP-A), SP-B, SP-C and SP-D respectively. SP-A and SP-D are hydrophilic surfactant proteins and are members of the collectin family. SP-B and SP-C are hydrophobic surfactant proteins and may be the most appropriate indicators for the evolutionary origin of surfactant. SP-B is synthesized by the alveolar type II epithelial cells as a 40-42 kD precursor that is subsequently proteolytically processed to 7.8-8 kD. SP-B enhances the spreading and stability of surfactant phospholipids in the alveolus. SP-B is essential for air-breathing in mammals and is therefore largely conserved. SP-B can interact with both phospholipid head groups and fatty chains and is particularly active in enhancing surface active behaviour in endogenous and exogenous lung surfactants. Even low SP-B contents had measurable effects in increasing the adsorption, dynamic surface tension lowering, and/or film respreading of DPPC, mixed synthetic lipids, and column-purified lung surfactant phospholipids. Deficiency of SP-B and other surfactant components is associated with respiratory distress syndrome (RDS) in premature infants and adults with respiratory distress syndrome (ARDS). The polyclonal antibody is raised against human-based 60-amino acid synthetic SP-B polypeptide. The antibody recognizes proteins of 42, 25 and 18 kD under nonreducing conditions. The 18 kD form is reduced to 7.7-8 kD in the presence of beta-mercaptoethanol. The polyclonal antibody is cross reactive with mouse, bovine and pig SP-B.
Immunogen	n/a
Other Names	SFTPB, previous SFTP3
Gene, Accession #	n/a
Catalog #	HP9049
Price
Order / More Info	SP-B, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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