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產(chǎn)品名稱

SR-A, Mouse Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HM1061

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	SR-A, Mouse
Clone	2F8
Host Species	Rat
Reactive Species	mouse
Isotype	IgG2b
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, IP, WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody 2F8 recognizes mouse scavenger receptor class A (SR-A), type I and II, also known as CD204. SR-A belongs to the group of scavenger receptors, which are divided in class A, B, D and E. Class A scavenger receptors (SRs) are multi-domained membrane glycoproteins that can endocytose modified lipoproteins and bind a wide range of ligands. SR-A is expressed by tissue macrophages and functions both as an endocytic receptor for lipoproteins and as an adhesion receptor for macrophages binding to ligand rich tissues e.g. atherosclerotic lesions. Tissue macrophage- populations that express SR-A I and II include those of the marginal zone of the spleen, alveolar macrophages, heart and gut. SR-A binds bacterial pathogens and is considered to play a role in the innate immune response. TLR2 and TLR4 agonists synergistically up-regulate SR-A in RAW264.7 through p38 pathway. SR-A knockout mice are more susceptible to endotoxic shock than wild type mice, which suggests a role in the clearance of bacterial endotoxin from the circulation. Using thymic macrophages of the knockout mice as well as antibody treatment confirmed that SR-A is responsible for half of the phagocytic activity required for apoptotic thymocyte ingestion. Next to its role in innate immunity there is evidence that SR-A also contributes to acquired immune responses. Monoclonal antibody 2F8 recognizes an epitope within the αhelical coiled-coil domain of SR-A in all mouse strain tested, with the exception of C57BL/6. One amino-acid change (L168S), due to polymorphism, results in the loss of reactivity of antibody 2F8.
Immunogen	RAW.264 cells (αhelical coiled coil domain CD204)
Other Names	CD204
Gene, Accession #	n/a
Catalog #	HM1061
Price
Order / More Info	SR-A, Mouse Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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