久草A片,成人激情在线观看,男女黄色视频在线观看,台湾精品一区二区,色播在线五月天,最近中文字幕mv第一季歌词免费,午夜福利一区二区区三区四区五,午夜在线一区

<button id="eiezk"><video id="eiezk"></video></button>

產(chǎn)品名稱

sTREM-1, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號

HM2304

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

Edit	&nbsp
Antigenic Specificity	sTREM-1, Human
Clone	15G7
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	immunoassay
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody 15G7 recognizes human triggering receptor expressed on myeloid cells 1 (TREM-1). TREM-1 is member of a family of cell surface receptors which function as modulators of the inflammatory response in sepsis. TREM-1 is widely expressed on cells of the myeloid lineage and acts as an inflammatory trigger and amplifier after fungal and bacterial contact. Expression is predominantly seen on neutrophils, monocytes, macrophages, microglia, osteoclasts and dendritic cells. The TREM family consist of TREM-1, TREM-2, TREM-3 (mouse) and TREM-like transcript 1&2. They are members of the transmembrane immunoglobulin superfamily. TREM-1 is a 30 kD monomeric protein synthesized as a 234 amino acid (aa) precursor with a signal peptide (16 aa), an extracellular domain (184 aa), a transmembrane domain (29 aa), and a short cytoplasmic domain (5 aa). The ligand of TREM-1is unknown. The engagement of TREMs, after association with the adapter protein DAP12 (DNA activating protein 12) which contains an immunoreceptor tyrosine-based activation motif, triggers a signalling pathway that leads to intracellular calcium mobilization, actin cytoskeleton rearrangement, and activation of several transcription factors. TREM-1 acts in synergy with Toll-like receptor signaling pathways in amplifying the inflammatory response. During infections, receptor expression is modulated and soluble TREM-1 (sTREM-1, 17 kDa) is released. TREM-1 is shed from the membrane of activated phagocytes and can be found as sTREM-1 in tissue and body fluids like plasma and bronchoalveolar lavage fluid (BAL). Some studies suggest that sTREM1 is transcribed from an alternative mRNA. sTrem-1 is unable to transmit a signal but competes for binding with endogenous ligands. Thereby dampen the amplification loop which is activated when the infection is started. sTREM1 levels are possibly a prognostic marker for sepsis. However, some other studies show also elevated levels in non-infectious causes of inflammation (e.g. Crohn disease). At least sTREM-1 in biological fluids often correlates with severity of disease.
Immunogen	sTREM-1
Other Names	soluble Triggering receptor expressed on myeoloid cells 1
Gene, Accession #	n/a
Catalog #	HM2304
Price
Order / More Info	sTREM-1, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

<button id="eiezk"><video id="eiezk"></video></button>