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產(chǎn)品名稱

TLR1, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2086

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	TLR1, Human
Clone	GD2.F4
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	biotin conjugate
Size	50 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, immunoassay, IF, paraffin sections
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	The monoclonal antibody GD2.F4 reacts with human TLR1. Toll-like receptors (TLR) are highly conserved throughout evolution and play an essential role in recognizing conserved motifs found in various pathogens and initiating an appropriate innate immune response. In human, ten members of the TLR family have been identified as type I transmembrane signaling receptors containing multiple copies of leucine rich repeats in the extracellular domain and an interleukin-1 (IL-1) receptor motif in the cytoplasmic domain. Mammalian responsiveness to microbial products may be mediated by combinations of TLRs, for example a co-operative effect is observed between TLR1 and TLR2- in response to bacterial lipoproteins. On the other hand, TLR 1 was shown to have the capacity to abrogate TLR4 signaling. In general, TLR1 is expressed at higher levels as compared to other TLRs. The highest expression of TLR1 is found in monocytes but it can also be expressed by macrophages, dendritic cells, B, T, and NK cells. In recent studies, several human TLR1 polymorphisms have been associated with impaired mycobacterial signaling and susceptibility to tuberculosis.
Immunogen	HeLa cells transfected with TLR1 mRNA (Ref.1)
Other Names	CD281, toll-like receptor 1, TLR1Fc
Gene, Accession #	n/a
Catalog #	HM2086
Price
Order / More Info	TLR1, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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