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產(chǎn)品名稱(chēng)

IGF-1R, Human Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM2340

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	IGF-1R, Human
Clone	1B1
Host Species	Rat
Reactive Species	human
Isotype	IgG2b
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	FC, immunoassay, IF
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody HM2340, clone 1B1 recognizes human insulin growth factor 1 receptor. IGF-1R is a heterotetrameric transmembrane tyrosine kinase receptor expressed by many cells like lymphoid and myeloid cells as well as non haematopoietic cells. The receptor consists of two extracellular α subunits and two β subunits with tyrosine kinase activity. Receptor autophosphorylation follows by binding of its ligands insulin-like growth factor 1 and 2. The IGF/IGF-1R pathway plays important and diverse roles in tissue development and function, cell cycle progression, apoptosis and translation of proteins. IGF-1R regulates normal as well as pathological responses opening opportunities for therapeutic intervention. IGF-1R bears structural and functional resemblance to other tyrosine kinase receptors. Upon IGF binding the receptor is activated and autophosphorylated at the tyrosine residues in intracellular subunits leading to signaling via MAPK and PI3K/Akt pathways. Many tumors and transformed cells have altered IFG-1R expression. Recently the receptor came under the attention of roles in immune regulation. Proinflammatory cytokines, of which many share signaling components like Erk MAP kinases, seem to dampen several components of the IGF pathway. Furthermore, IGF regulates diverse aspects of T-cell, B-cell and monocyte function suggesting a role in pathogenesis of diseases where immunity is altered, like rheumatoid arthritis and IBD. Antibody 1B1 recognizes the extracellular domain if IGF-1R.
Immunogen	Recombinant IGF-1R (aa 1-932)
Other Names	Insulin-like growth factor 1 receptor, IGF-I receptor, IGF-1R, CD221.
Gene, Accession #	IGF1R
Catalog #	HM2340
Price
Order / More Info	IGF-1R, Human Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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