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產(chǎn)品名稱

TLR2, Mouse Antibody from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HM1092

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	TLR2, Mouse
Clone	mT2.4
Host Species	Mouse
Reactive Species	mouse
Isotype	IgG2b
Format	unconjugated
Size	100 μg
Concentration	100 μg/ml
Applications	frozen sections, FC, functional studies, immunoassay, paraffin sections
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Monoclonal antibody mT2.4 reacts with mouse Toll-like receptor 2 (TLR2, CD282). Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defense to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defenses. In mammals, TLR identified as type I transmembrane signaling receptors with pattern recognition capabilities, have been implicated in the innate host defense to pathogens. TLR2 has been identified as a receptor that is central to the innate immune response to lipoproteins of Gram-negative bacteria, several whole Gram-positive bacteria, as well as a receptor for peptidoglycan and lipoteichoic acid and other bacterial cell membrane products. A functional interaction between TLR2 and TLR6 in the cellular response to various bacterial products has been discovered. The currently accepted paradigm regards TLR2 as an essential receptor for many eubacterial cell wall components, including lipoproteins and peptidoglycan. Bacterial species as diverse as mycobacteria, spirochetes, mycoplasma, Staphylococcus aureus, and Streptococcus pneumoniae have all been shown to mediate cellular activation via TLR2. The monoclonal antibody mT2.4 inhibits murine TLR2-mediated cell activation. It masks the lipopeptide binding site in the recombinant extracellular domain of TLR2 (TLR2ECD) and does not hinder the receptor complex formation. The antibody reacts with the native TLR2 protein and not with denatured TLR2 protein . Furthermore the antibody stains overexpressed, as well as endogenous cell surface- and intracellular mouse TLR2.
Immunogen	n/a
Other Names	n/a
Gene, Accession #	n/a
Catalog #	HM1092
Price
Order / More Info	TLR2, Mouse Antibody from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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