| 產品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | PTX3, Human |
|---|
| Clone | MNB4 |
|---|
| Host Species | Rat |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a |
|---|
| Format | unconjugated |
|---|
| Size | 0.5 mg |
|---|
| Concentration | n/a |
|---|
| Applications | frozen sections, FC, immunoassay, IF, IP, paraffin sections, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody MNB4 (previously known as clone 20) recognizes human pentraxin 3 (PTX3), belonging to the long pentraxin family. PTX3 is an acute-phase glycoprotein of ~45 kDa with glycosylation accounting for about 10% of its molecular weight. PTX3 has a complex oligomeric structure with protomers linked to each other by disulfide bonds. PTX3 expression is triggered by inflammatory cytokines, resulting in higher levels of circulating PTX3. Several cell types have been reported to produce PTX3, namely macrophages, endothelial cells, neutrophils and synoviocytes. PTX3 is involved in host defense against pathogen infection, in the regulation of the scavenger activity of macrophages and dendritic cells, and in modulation of complement activity by binding to C1q. Furthermore, PTX3 has been implicated in matrix deposition of cumulus cells. Moreover, PTX3 interacts with other biologically active molecules, causing their functional blockade. This has been demonstrated for fibroblast growth factor-2 (FGF-2), for which PTX3 acts as an inhibitor, leading to inhibition of angiogenesis. PTX3, like other pentraxins C-reactive protein (CRP) and serum amyloid P component (SAP), binds apoptotic cells and debris. PTX3 is useful as an early indicator of myocyte irreversible injury in ischemic cardiomyopathy. PTX3 is not only involved in inflammatory vessel diseases related to atherosclerosis, but also in pre-eclampsia and systemic small vessel ANCA-associated vasulitis, in which neutrophils are key players. The relationship between tissue damage and pentraxin generation is stringent in acute injuries. PTX3 tunes self-non-self discrimination and tissue repair due to the recognition of diverse ligands by PTX3 and through regulation of effector pathways. |
|---|
| Immunogen | Human recombinant PTX3 |
|---|
| Other Names | Pentraxin-related protein PTX3, Tumor necrosis factor-inducible gene 14 protein, TSG-14 |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM2242-IA |
|---|
| Price | |
|---|
| Order / More Info | PTX3, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產品資料 |
|
影音先锋男人网站,操初中女生,精品在线视频网
|
黄色片入口,国产三级无码,操屄免费看
|
最新操逼视频,国产97色在线,天天干天
|
www.黄色小说,1v1被强行糟蹋h,欧美精品不卡免费在线
|
日批网站视频,久久久久久免费视频,日韩婬乱a一级毛片无码
|
精品人妻二区三区蜜桃,午夜三级电影,欧美女人性爱视频
|
天天操夜夜拍拍免费观看,韩国三级做爰高潮hd,午夜亚洲精品
|
人人看人人摸人人草,国产午夜小视频,亚洲精品综合在线观看
|
国产美女精品视频,丰满秘书高清大乳在线观看0,污污污污污污
|
噜噜色av,女尊高h乱l高辣h文全文阅读,CaoPorn国产精品免费收藏
|
|