| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Siglec-H, Mouse |
|---|
| Clone | 44c |
|---|
| Host Species | Rat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG2b |
|---|
| Format | biotin conjugate |
|---|
| Size | 50 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | frozen sections, FC |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 440c reacts with Siglec-H, a cell-surface receptor molecule selectively expressed on murine natural interferon producing cells (IPC), also called mouse plasmacytoid dendritic cells (pDC). Siglec H is unique among Sialic acid-binding Ig-like lectins (Siglecs) proteins because it associates with the adaptor protein DAP12. DAP12 recognize certain viruses and CpG-DNA through TLR9, resulting in secretion of IFN-alpha, IL-12 and proinflammatory chemokines. Together these cytokines and chemokines recruite and activate NK cells and T cells as well as modulating the antigen presenting function of dendritic cells (DC). IPC themselves also function as antigen presenting cells that expand memory T cells and induce Th1 differentiation. Therefore IPC may provide a first line of host defense against viral infections by activating both innate and adaptive responses in vivo. The monoclonal antibody 440c exclusively recognizes mouse Siglec-H in all lymphoid organs under both normal and inflammatory conditions. Siglec-H is normal present in the T cell zone of lymph nodes and spleen. Incubation of IPC with antibody 440c in vitro or administration of antibody 440c in vivo reduces secretion of IFN-alpha in response to CpG DNA without causing IPC depletion. |
|---|
| Immunogen | n/a |
|---|
| Other Names | n/a |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM1095 |
|---|
| Price | |
|---|
| Order / More Info | Siglec-H, Mouse Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
精品黄工厂在线观看,撕开奶罩揉吃奶高潮av在线,岛国成人人妻系列AV
|
亚洲少妇网,动漫巨大房乳挤奶动漫,一级a做一级a做片性视频爱小说
|
麻婆传媒,艳母旧里番,黄片靠逼
|
学生妹A级片,国产香蕉久久,国内精品国产成人三级
|
人妻无码一区二区三区久,国产视频久久久久久久,黄色AAA片
四虎视频国产精品免费看,欧美一级影视,丁香五月天天操天天爽
|
三级无码在线,日本少妇精品亚洲第一区,成人无遮挡在线免费视频
|
噜噜噜私人影院,欧美日韩不卡合集视频,日本最大的黄色网址
|
黄网一区,日本狠狠干,热久精品
|
91干比,国产精品wwww,亚洲视频日本
|
骚逼h,国产精品露脸自拍,久久99色
|
|