| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | SIRL-1, Human |
|---|
| Clone | 1A5 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG1 |
|---|
| Format | unconjugated |
|---|
| Size | 100 μg |
|---|
| Concentration | 100 μg/ml |
|---|
| Applications | FC, functional studies, IP, WB |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | The monoclonal antibody 1A5 recognizes human Signal inhibitory Receptor on Leucocytes-1 (SIRL-1). In order to prevent host tissue damage immune activation has to be tighly regulated. Neutrophils and other myeloid cells have a pivotal role in controlling infection. They form the primary response at site of infection as they regulate replication of pathogens by phagocytosis, secretion of antimicrobial peptides and proinflammatory cytokines to activate the immune system. Without regulation these mediators can cause tissue damage or worse. To balance the immune response immune cells can express inhibitory receptors. The family of immune inhibitory receptors is still expending. The relatively new receptor SIRL-1 is an immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing membrane protein expressed on human phagocytes. SIRL-1 contains two ITIMs in the intracellular tail, which are crucial for function. SIRL-1 can recruit the SH2-domain containing tyrosine phosphatases, SHP-1 and SHP-2, which may mediate the inhibitory effect. ITIM-bearing receptors inhibit signals relayed by immunoreceptor tyrosine-based activating motifs (ITAMs). ITAMs are the principal mediators of signal transduction for various receptors, including FcRs and C-type lectins. The ligation of SIRL-1 dampens Fc receptor induced ROS production in phagocytes, thereby impairing the microbicidal activity of neutrophils without affecting phagocytosis. Infectious stimuli cause rapid downregulation of SIRL-1 expression. This allows microbial killing and clearance of pathogens. Neutrophil extracellular traps (NETs) have been implicated in the pathogenesis of systemic lupus erythematosus (SLE). Using anti SIRL-1 antibodies both spontaneous anti-neutrophil antibody induced NET formation is suppressed. This suggests a regulatory role for SIRL-1 in NET formation and a therapeutic target for regulation of SLE. |
|---|
| Immunogen | Purified SIRL-1-hIg fusion protein in PBS |
|---|
| Other Names | V-set and transmembrane domain-containing protein 1, Signal inhibitory receptor on leukocytes-1 |
|---|
| Gene, Accession # | n/a |
|---|
| Catalog # | HM2309 |
|---|
| Price | |
|---|
| Order / More Info | SIRL-1, Human Antibody from HYCULT BIOTECH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
jiZZ亚洲女人高潮大叫,国产精品免费麻豆入口,看b网站
|
天天操天天舔,中国女人野外做爰a正片,国产亚洲精品电影
|
日本国产高清视频,欧美bb片,男人午夜
|
天天爽日韩中文字幕综合一区,韩国电影黄色片,日韩人妻无码一区二区三区四区
|
欧美午夜性爱视频,久久久久三级,美女网站免费
|
青娱乐在线观看,一级片麻豆,秋霞网一曲二曲
|
久一国产,夜夜操夜夜爱,黄色黄片网址
|
女人下身被添全过A片一级,少妇紧身牛仔裤啪啪,一区日韩
|
免费插逼视频,欧美日韩国产伦理,玖玖视频精品
|
黄色一级肏逼视频,午夜毛片影院,亚洲尤物在线
|
|