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產(chǎn)品名稱

VEGF-A ELISA (Vascular Endothelial Growth Factor-A ELISA) from ALPCO

產(chǎn)品貨號

61-VGAHU-E01

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

96 wells

產(chǎn)品品牌

ALPCO

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	VEGF-A ELISA (Vascular Endothelial Growth Factor-A ELISA)
Description	One of the key molecules for angiogenesis and for the survival of the endothelium is vascular endothelial growth factor (VEGF-A). It is a specific endothelial cell mitogen and a strong vascular permeability factor (VPF). VEGF-A is a heparin-binding glycoprotein, secreted as a homodimer of 45 kDa by many different cell types. VEGF-A also causes vasodilation through the nitiric oxide synthase pathway in endothelial cells and can activate migration in monocytes. Many different splice variants of VEGF-A have been described, but VEGF165 is the most predominant protein and anchors with its heparin binding domain to extracellular matrix and to heparin sulfate. Examples where VEGF-A plays an important role are psoriasis andrheumatoid arthritis, as well as the ovarian hyperstimulation syndrome. Diabetic retinopathy is associated with high intraocular levels of VEGF-A, and inhibition of VEGF-A function may result in infertility by blockage of corpus luteum function. Direct demonstration of the importance of VEGF-A in tumor growth has been achieved using dominant negative VEGF receptors to block in vivo proliferation, as well as blocking antibodies to VEGF or to one of the VEGF receptors. VEGF-A transcription is highly activated by hypoxia and by oncogenes like H-ras and several transmembrane tyrosine kinases, such as epidermal growth factor receptor and ErbB2. Together these pathways account for a marked upregulation of VEGF-A in tumors compared to normal tissues and are often of prognostic importance and relevance. Targeting the VEGF signalling may be of major therapeutic importance for many diseases and serves as a basis for the design of future (anti)-angiogenic treatments. Sample Types: Human cell culture, citrate plasma, EDTA plasma, heparin plasma, serum. Sample Size: 50 μL. Range: 15.6 - 1,000 pg/mL. Sensitivity: 7.9 pg/mL. Time: 4hr 30min
Size	96 wells
Concentration	n/a
Applications	Immunoassays. Research Use Only. Not for Use in Diagnostic Procedures.
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	61-VGAHU-E01
Price
Order / More Info	VEGF-A ELISA (Vascular Endothelial Growth Factor-A ELISA) from ALPCO
Product Specific References	n/a
產(chǎn)品資料

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