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產(chǎn)品名稱

Calprotectin, Human, Recombinant from HYCULT BIOTECH

產(chǎn)品貨號

HC2120

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Calprotectin, Human, Recombinant
Description	Calprotectin, also known as MRP-8/MRP-14 or S100A8/A9 heterocomplex, is formed out of the calcium-binding, migration inhibitory factor-related proteins, MRP-8 (S100A8) and MRP-14 (S100A9). The expression of these proteins is largely confined to the cytosol of neutrophils and monocytes. The complex formation of these proteins is calcium-dependent. Calprotectin comprises 60% of the cytoplasmic protein fraction of circulating polymorphonuclear granulocytes and is also found in monocytes, macrophages and ileal tissue eosinophils. Peripheral blood monocytes carry the antigen extra- and intracellularly, neutrophils only intracellularly. Calprotectin has antibacterial, antifungal, immunomodulating and antiproliferative effects. Furthermore, it is a potent chemotactic factor for neutrophils. Plasma concentrations are elevated in diseases associated with increased neutrophil activity. During intestinal wall inflammation, granulocytes transmigrate through the intestinal wall. Therefore calprotectin is also detectable in faeces. Several investigations report that faecal calprotectin is significantly increased in intestinal diseases such as inflammatory bowel disease (IBD), Crohn's disease, ulcerative colitis and colon cancer. Normal human plasma contains a calprotectin concentration ranging from 500 to 3000 ng/ml.
Size	50 μg
Concentration	Lyophilized product in 74mM Tris-HCl and 104mM NaCl, pH7.4 containing 50 μg human Calprotectin.
Applications	functional studies
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	HC2120
Price
Order / More Info	Calprotectin, Human, Recombinant from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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