| Description | A TLR7 agonist (EC50 = 2.12 μM); increases TNF-α and IL-12 p40 production in IFN-γ-treated murine peritoneal macrophages in a concentration- and MyD88-dependent manner; topical application of a 5% cream increases TNF and IFN levels at the application site in hairless mice; dose-dependently increases serum levels of IFN-α in mice when administered by gavage; reduces tumor growth in an MC-26 model of murine colon cancer at 30 mg/kg every three days; reduces vaginal viral titer and lesion formation in a guinea pig model of genital HSV-2 infection at 5 mg/kg, intravaginally, twice daily |
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