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| Antigenic Specificity | CD274 (B7-H1, PD-L1) |
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| Clone | 10F.9G2 |
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| Host Species | Rat |
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| Reactive Species | mouse |
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| Isotype | IgG2b, κ |
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| Format | purified |
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| Size | 50 μg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), Immunofluorescence Microscopy (IF) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-mouse CD274 (B7-H1, PD-L1). CD274, also known as B7-H1 or programmed death ligand 1 (PD-L1), is a 40 kD type I transmembrane protein and a member of the B7 family within the immunoglobulin receptor superfamily. It is expressed on T cells, B cells, NK cells, dendritic cells, IFN-γ activated endothelial cells, and monocytes. B7-H1 is one of the ligands of PD-1. The interaction of B7-H1 with PD-1 plays an important role in the inhibition of T cell responses. Other studies have shown that B7-H1 is able to costimulate T cell growth and cytokine production. CD274 is involved in costimulation essential for T cell proliferation and production of IL-10 and IFN-γ, in an IL-2-dependent and a PD-1-independent manner. Its interaction with PD-1 inhibits T cell proliferation and cytokine production. |
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| Immunogen | n/a |
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| Other Names | B7-H1, PD-L1 |
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| Gene, Accession # | Gene ID: 60533 |
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| Catalog # | 124301 |
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| Price | |
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| Order / More Info | CD274 (B7-H1, PD-L1) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 17003438,22351930,24039898,25404033 |
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