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| Antigenic Specificity | CD274 (B7-H1, PD-L1) |
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| Clone | 29E.2A3 |
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| Host Species | Mouse |
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| Reactive Species | human, African green, baboon, cynomolgus, rhesus |
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| Isotype | IgG2b, κ |
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| Format | purified, azide-free |
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| Size | 1 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IHC, Block |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Ultra-LEAF? Purified anti-human CD274 (B7-H1, PD-L1). CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production?in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
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| Immunogen | Full length human PD-L1 |
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| Other Names | Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1) |
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| Gene, Accession # | Gene ID: 29126 |
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| Catalog # | 329716 |
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| Price | |
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| Order / More Info | CD274 (B7-H1, PD-L1) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 26604307 |
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