| Edit |   |
|---|
| Antigenic Specificity | Human CD274 (B7-H1, PD-L1) |
|---|
| Clone | 29E.2A3 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human, African green, baboon, cynomolgus, rhesus |
|---|
| Isotype | IgG2b, κ |
|---|
| Format | TotalSeq?-B oligomer conjugate |
|---|
| Size | 10 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Proteogenomics. TotalSeq? reagents are designed to profile protein expression at a single cell level following an optimized protocol similar to the CITE-seq workflow. |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | TotalSeq?-B0007 anti-human CD274 (B7-H1, PD-L1). CD274, also known as PD-L1 and B7-H1, is type I transmembrane glycoprotein that serves as a ligand for CD279 (PD-1). This interaction is believed to regulate the balance between the stimulatory and inhibitory signals needed for responses to microbes and maintenance of self-tolerance. CD274 is involved in the costimulation of T cell proliferation and IL-10 and IFN-γ production in an IL-2-dependent and CD279-independent manner. Conflicting data has shown that CD274 can inhibit T cell proliferation and cytokine production, and alternatively, enhance T cell activation. Other studies suggest that CD274 may signal bidirectionally, raising interesting implications for its expression in a wide variety of cell types, including T and B cells, antigen-presenting cells, and nonhematopoietic cells. |
|---|
| Immunogen | Full length human PD-L1 |
|---|
| Other Names | Programmed cell death ligand 1 (PD-L1), B7 homolog 1 (B7-H1) |
|---|
| Gene, Accession # | Gene ID: 29126 |
|---|
| Catalog # | 329749 |
|---|
| Price | |
|---|
| Order / More Info | Human CD274 (B7-H1, PD-L1) Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|