| 產(chǎn)品詳情 |
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| Antigenic Specificity | Interleukin 33 (IL33) |
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| Clone | IL33305B |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | unconjugated |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | ELISA,Functional Studies (Func),Immunohistochemistry (IHC),Immunoprecipitation (IP),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Interleukin-33 (IL-33, HF-NEV, IL-1F11), a member of the IL-1 family of cytokines, is expressed by many cell types following pro-inflammatory stimulation and is thought to be released on cell lysis. The 30kDa human IL33 is converted by CASP1 to a 18kDa protein. IL33 binds to and signals through ST2 (IL1R1) and its stimulation recruits MYD88, IRAK, IRAK4, and TRAF6, followed by phosphorylation of ERK1 (MAPK3)/ERK2 (MAPK1), p38(MAPK14), and JNK. The ability of IL-33 to target numerous immune cell types, like Th2-like cells, mast cells, and B1 cells, and to induce cytokine and chemokine production underlines its potential in influencing the outcome of a wide range of diseases, such as arthritis, asthma, atopic allergy & anaphylaxis, cardiovascular disease/atherosclerosis, nervous system diseases, and sepsis. |
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| Immunogen | Recombinant human IL-33. |
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| Other Names | IL33|C9orf26|DVS27|IL1F11|NF-HEV|NFEHEV|RP11-575C20.2|9230117N10Rik|Il-33|Il1f11|RGD1311155 |
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| Gene, Accession # | Gene ID: 90865 |
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| Catalog # | ABIN1169172 |
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| Price | |
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| Order / More Info | Interleukin 33 (IL33) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 24931101, 19248109, 19204726, 19465481 |
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