| 產(chǎn)品詳情 |
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| Antigenic Specificity | Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (aa 45-59), (N-Term) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IRAK-4(interleukin-1 receptor-associated kinase 4), also called REN64, in the IRAK family, is a protein kinase involved in signaling innate immune responses from Toll-like receptors. It also supports signaling from T-cell receptors. Scott(2002) mapped the REN64/IRAK4 gene to chromosome 12 based on similarity between the REN64 sequence(GenBank AF155118) and a chromosome 12 clone(GenBank AC093012). Functional analysis by Li et al.(2002) determined that IRAK4, like IRAK1 and Pelle, has auto- and cross-phosphorylation kinase activity. Precipitation and binding analyses showed weak interaction between IRAK4 and IRAK1, but IRAK4 did not interact with other IRAK family members. Overexpressed IRAK4 interacted with MYD88 and TRAF6 and activated mitogen-activated protein kinase(MAPK) and nuclear factor kappa-B(NFKB) pathways. |
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| Immunogen | A synthetic peptide corresponding to a sequence at the N-terminus of human IRAK4(45-59aa DDRYNQFHIRRFEAL), identical to the related rat and mouse sequences. |
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| Other Names | zgc:55553|IRAK4|ipd1|irak-4|ny-ran-64|ny-ren-64|ren64|irak4|IPD1|IRAK-4|NY-REN-64|REN64|8430405M07Rik|9330209D03Rik |
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| Gene, Accession # | Gene ID: 51135 |
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| Catalog # | ABIN1673421 |
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| Price | |
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| Order / More Info | Interleukin-1 Receptor-Associated Kinase 4 (IRAK4) (aa 45-59), (N-Term) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 15069404, 11960013 |
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