| Edit |   |
|---|
| Antigenic Specificity | Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 100 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | A20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB. It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790 AA protein containing seven Cys2/Cys2-zinc finger motifs. Constitutive expression of A20 is observed in lymphoid tissues , but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha , IL-1 , phorbol esters , and LPS. Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members , and interaction with the NF-kappaB inhibiting protein ABIN. Studies also show that A20 contains site-specific ubiquitin modifying activity that can contribute to its biological functions. The amino-terminus of A20 contains de-ubiquitinating (DUB) activity for Lys63 branches, such as those found in TRAF6 and RIP, while the carboxyl-terminus contains ubiquitin ligase (E3) activity for Lys48 branches of the same substrates and leads to their degradation.Synonyms: A20, MGC104522, MGC138687, MGC138688, OTUD7C, TNFA1P2 |
|---|
| Immunogen | Recombinant protein of human TNFAIP3 |
|---|
| Other Names | tnfaip3|MGC82339|TNFAIP3|A20|OTUD7C|TNFA1P2|Tnfip3 |
|---|
| Gene, Accession # | Gene ID: 7128,21929,683206 |
|---|
| Catalog # | ABIN1513620 |
|---|
| Price | |
|---|
| Order / More Info | Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|