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        產(chǎn)品名稱 Tumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibody from ANTIBODIES-ONLINE GmbH
        產(chǎn)品貨號(hào) ABIN1684053
        產(chǎn)品價(jià)格 現(xiàn)貨詢價(jià),電話:010-67529703
        產(chǎn)品規(guī)格 50 μg
        產(chǎn)品品牌 ANTIBODIES-ONLINE GmbH
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic SpecificityTumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3)
        Clonepolyclonal
        Host SpeciesRabbit
        Reactive Speciesmouse, rat, human
        Isotypen/a
        Formataffinity purified
        Size50 μg
        Concentrationn/a
        ApplicationsWestern Blotting (WB),Immunohistochemistry (IHC)
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionA20, also referred to as TNF-alpha-induced protein 3 (TNFAIP3), is cytokine-inducible protein that functions to inhibit apoptosis and activate NF-kappaB . It was first identified as a TNF-alpha inducible primary response gene in human umbilical vein endothelial cells, and encodes a 790-amino acid protein containing seven Cys2/Cys2-zinc finger motifs . Constitutive expression of A20 is observed in lymphoid tissues , but it is transiently expressed in a variety of cell types in response to inflammatory signals such as TNF-alpha , IL-1 , phorbol esters , and LPS . Expression of A20 can confer resistance to apoptosis and NF-kappaB activation triggered by these signals, probably through interference with TRAF (TNF receptor associated factor) family members , and interaction with the NF-kappaB inhibiting protein ABIN . Studies also show that A20 contains site-specific ubiquitin modifying activity that can contribute to its biological functions . The amino-terminus of A20 contains de-ubiquitinating (DUB) activity for Lys63 branches, such as those found in TRAF6 and RIP, while the carboxyl-terminus contains ubiquitin ligase (E3) activity for Lys48 branches of the same substrates and leads to their degradation . Synonyms: A20, MGC104522, MGC138687, MGC138688, OTUD7C, TNFA1P2,
        ImmunogenRecombinant protein of human TNFAIP3
        Other Namestnfaip3|MGC82339|TNFAIP3|A20|OTUD7C|TNFA1P2|Tnfip3
        Gene, Accession #Gene ID: 7128,21929,683206
        Catalog #ABIN1684053
        Price
        Order / More InfoTumor Necrosis Factor, alpha-Induced Protein 3 (TNFAIP3) Antibody from ANTIBODIES-ONLINE GmbH
        Product Specific Referencesn/a
        產(chǎn)品資料
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