| 產(chǎn)品詳情 |
| Edit |   |
|---|
| Antigenic Specificity | Toll-Like Receptor 7 (TLR7) |
|---|
| Clone | polyclonal |
|---|
| Host Species | Rabbit |
|---|
| Reactive Species | mouse, rat, human |
|---|
| Isotype | n/a |
|---|
| Format | affinity purified |
|---|
| Size | 100 μg |
|---|
| Concentration | n/a |
|---|
| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TLR7, 8 and 9 form a group of structurally related TLR family members that are are localized to intracellular endosomes. TLR7 shows highest expression in lung, placenta, and spleen. TLR7 mediates responses to a class of synthetic compounds, including imidazoquinolines, guanosine-based drugs that induce anti-viral responses. Naturally, TLR7 responds to ssRNA viruses to activate NF-kappaB and trigger IFN production.Synonyms: TLR7 |
|---|
| Immunogen | Recombinant protein of human TLR7 |
|---|
| Other Names | TLR7A|TLR7-like|RGD1563357 |
|---|
| Gene, Accession # | Gene ID: 51284,170743,317468 |
|---|
| Catalog # | ABIN1513615 |
|---|
| Price | |
|---|
| Order / More Info | Toll-Like Receptor 7 (TLR7) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | n/a |
|---|
| 產(chǎn)品資料 |
|
黄色片在线播放,啊啊啊水好多,插骚视频
|
漫蛙manwa防走失站漫画软件测评,免费A级毛片无码免费120软件,99精品在线播放
|
69极品少妇一区二区,成人中文字幕在线视频,91偷情视频
|
BBBBBBBBB成人免费毛片,干日本少妇首页,yy6080伦理
|
日本免费高清一区二区三区,色悠悠久久综合,欧美激情精品成人
|
成人人伦一区二区三区,国产精品激情,91无码精品人妻一区二区
|
av在线资源网,密臀av一区二区,干了四年的金毛都没事
|
影音先锋人妻,午夜啪啪剧场,在线三级片视频
|
久青草资源福利视频,女人被爽到高潮的乱码网站,国产精品久久久久久久久久中字幕
|
欧美操逼网欧美操逼网,在线观看黄色电影,亚洲精品黄色电影
|
|