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產(chǎn)品名稱

Toll-Like Receptor 7 (TLR7) Antibody from ANTIBODIES-ONLINE GmbH

產(chǎn)品貨號

ABIN1684050

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

ANTIBODIES-ONLINE GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Toll-Like Receptor 7 (TLR7)
Clone	polyclonal
Host Species	Rabbit
Reactive Species	mouse, rat, human
Isotype	n/a
Format	affinity purified
Size	50 μg
Concentration	n/a
Applications	Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses . TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TLR7, 8 and 9 form a group of structurally related TLR family members that are are localized to intracellular endosomes . TLR7 shows highest expression in lung, placenta, and spleen . TLR7 mediates responses to a class of synthetic compounds, including imidazoquinolines, guanosine-based drugs that induce anti-viral responses . Naturally, TLR7 responds to ssRNA viruses to activate NF-kappaB and trigger IFN production . Synonyms: TLR7
Immunogen	Recombinant protein of human TLR7
Other Names	TLR7A\|TLR7-like\|RGD1563357
Gene, Accession #	Gene ID: 51284,170743,317468
Catalog #	ABIN1684050
Price
Order / More Info	Toll-Like Receptor 7 (TLR7) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific References	n/a
產(chǎn)品資料

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