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產(chǎn)品名稱

Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibody from ANTIBODIES-ONLINE GmbH

產(chǎn)品貨號

ABIN1513232

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100 μg

產(chǎn)品品牌

ANTIBODIES-ONLINE GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Myeloid Differentiation Primary Response Gene (88) (MYD88)
Clone	polyclonal
Host Species	Rabbit
Reactive Species	mouse, rat, human
Isotype	n/a
Format	affinity purified
Size	100 μg
Concentration	n/a
Applications	Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. MyD88 was originally isolated as a myeloid differentiation primary response gene that is rapidly induced upon IL-6 stimulated differentiation of M1 myeloleukemic cells into macrophages. It contains an amino-terminal death domain separated from a carboxyl-terminal TIR domain and functions as an adaptor in TLR/IL-1 receptor signaling. The death domain of MyD88 mediates interactions with the IRAK complex triggering a signaling cascade that includes the activation of NF-kappaB.Synonyms: MYD88D
Immunogen	Recombinant protein of human MyD88
Other Names	XMyD88\|myd88d\|MGC84928\|CG2078\|DMMYD88\|DmMyD88\|DmMyd88\|Dmel\\CG2078\|EP(2)2535\|Kra\|LD20892\|MYD88\|MyD88\|Myd88F\|dMyD88\|dMyd88\|kra\|myd88\|zgc:103541\|GB12344\|NV10640\|irak-2\|MYD88D
Gene, Accession #	Gene ID: 4615,17874,301059
Catalog #	ABIN1513232
Price
Order / More Info	Myeloid Differentiation Primary Response Gene (88) (MYD88) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific References	n/a
產(chǎn)品資料

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