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產(chǎn)品名稱

Toll Interacting Protein (TOLLIP) Antibody from ANTIBODIES-ONLINE GmbH

產(chǎn)品貨號(hào)

ABIN1514773

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

200 μg

產(chǎn)品品牌

ANTIBODIES-ONLINE GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Toll Interacting Protein (TOLLIP)
Clone	polyclonal
Host Species	Rabbit
Reactive Species	mouse, rat, human
Isotype	n/a
Format	affinity purified
Size	200 μg
Concentration	n/a
Applications	Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses. TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 AAs known as the Toll/Interleukin-1 receptor (TIR) domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains, including myeloid differentiation factor 88 (MyD88), MyD88-adaptor-like/TIR-associated protein (MAL/TIRAP), Toll-receptor-associated activator of interferon (TRIF), and Toll-receptor-associated molecule (TRAM). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB, which normally maintains NF-kappaB in an inactive state by sequestering it in the cytoplasm. Tollip (Toll interacting protein) is an adaptor protein discovered to be associated with the IRAK complex and recruited to IL1-R following IL-1 stimulation. Overexpression of Tollip results in impaired NF-kappaB signaling. Tollip also associates directly with TLR2 and TLR4 and inhibits TLR-mediated signaling through inhibition of IRAK. Studies of Tollip deficient mice suggest that it plays a role in the regulation of inflammatory cytokines in response to IL-1 and LPS.Synonyms: FLJ33531, IL-1RAcPIP
Immunogen	Recombinant protein of human TOLLIP
Other Names	IL-1RAcPIP\|TOLLIP\|GB17961\|4930403G24Rik\|4931428G15Rik\|fk22a02\|im:7145391\|wu:fk22a02\|zgc:76985\|tollip
Gene, Accession #	Gene ID: 54472,54473,361677
Catalog #	ABIN1514773
Price
Order / More Info	Toll Interacting Protein (TOLLIP) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific References	n/a
產(chǎn)品資料

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