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| Antigenic Specificity | CD271 |
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| Clone | ME20.4 |
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| Host Species | Mouse |
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| Reactive Species | human, African green, baboon, cynomolgus, rhesus |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IP, Western Blot (WB), IHC |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human CD271 (NGFR). CD271, also known as p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, and NGFR, is a type I transmembrane protein with a MW of 75 kD. It is expressed by many cell types including neurons, Schwann cells, mesenchymal stem/stromal cells, follicular dendritic cells and melanocytes. The extracellular portion contains four TNFR-Cys repeats that form the binding domain for its ligands (NGF, BDNF, NTF3, and NTF4). The intracellular portion of CD271 contains a death domain, which interacts with TRAF2, TRAF4, TRAF6, PTPN13 and RANBP9, to promote cell apoptosis, and to regulate cell differentiation and neurogenesis. |
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| Immunogen | WM245 melanoma cells |
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| Other Names | p75NTR, TNFRSF16, p75(NTR), Gp80-LNGFR, NGFR, Nerve Growth Factor Receptor |
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| Gene, Accession # | Gene ID: 4804 |
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| Catalog # | 345102 |
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| Price | |
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| Order / More Info | CD271 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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