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| Antigenic Specificity | CD283 (TLR3) |
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| Clone | TLR-104 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC), Western Blot (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human CD283 (TLR3). Toll-like receptor 3 (TLR3) is a 104 kD protein also known as CD283. It is expressed selectively on the cytoplasmic membrane and intracellularly in dendritic cells. TLR3 is also highly expressed in the placenta, pancreas, heart, liver, lung, and muscle. TLR3 is a pattern recognition receptor that participates in innate immune response to microbial pathogens. The ligands recognized by TLR3 are polyinosine-polycytidylic acid (Poly(I:C)) and dsRNA. TLR3 ligands induce NF-κB activation (via TRIF-linked RIP1/TLR3 interactions) and cytokine production. TLR3 has been shown to interact with a number of proteins including MYD88, TRAF6, TRIAD3, MAP3K7, and TAB2. This antibody is useful for flow cytometry and Western blotting. |
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| Immunogen | Recombinant human Toll-like receptor 3 protein |
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| Other Names | Toll like receptor 3, TLR-3 |
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| Gene, Accession # | Gene ID: 7098 |
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| Catalog # | 315002 |
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| Price | |
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| Order / More Info | CD283 (TLR3) Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18508883,19541850 |
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