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| Antigenic Specificity | IRF7 |
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| Clone | 12G9A36 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2b, κ |
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| Format | Alexa Fluor? 647 conjugate |
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| Size | 100 tests |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Alexa Fluor? 647 anti-IRF7. IRF-7 is a member of the interferon regulatory transcription factor family that plays key regulatory roles in innate immunity. Upon virus infection, IRF-7 forms a complex with MyD88 and TRAF6 when stimulated by toll-like receptors TLR7, TLR8, and TLR9, which in turn results in nuclear translocation and induction of interferon gene expression. IRF-7 gene expression is upregulated by the stimulation of interferon through the Jak-STAT signaling pathway, which forms a positive feedback loop. The protein level of IRF-7 after activation is then downregulated by the ubiquitin-proteasome system to avoid excessive production of interferons that may cause damage to the host. Virus induced type I interferon expression was completely abrogated in IRF-7 knockout mice, suggesting that IRF-7 is critical for interferon mediated host defense during virus infection. |
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| Immunogen | Partial IRF7 recombinant protein (127-503 a.a.) |
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| Other Names | Interferon regulatory factor-7 (IRF-7) |
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| Gene, Accession # | Gene ID: 3665 |
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| Catalog # | 656008 |
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| Price | |
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| Order / More Info | IRF7 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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