| Edit |   |
|---|
| Antigenic Specificity | CD357 (GITR) |
|---|
| Clone | 108-17 |
|---|
| Host Species | Mouse |
|---|
| Reactive Species | human |
|---|
| Isotype | IgG2a, κ |
|---|
| Format | APC-Fire? 750 conjugate |
|---|
| Size | 25 tests |
|---|
| Concentration | n/a |
|---|
| Applications | Flow Cytometry (FC) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | APC/Fire? 750 anti-human CD357 (GITR). GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. |
|---|
| Immunogen | Recombinant human GITR-Fc chimera |
|---|
| Other Names | TNFRSF18, Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR |
|---|
| Gene, Accession # | Gene ID: 8784 |
|---|
| Catalog # | 371221 |
|---|
| Price | |
|---|
| Order / More Info | CD357 (GITR) Antibody from BIOLEGEND |
|---|
| Product Specific References | n/a |
|---|