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| Antigenic Specificity | GITR |
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| Clone | 621 |
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| Host Species | Mouse |
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| Reactive Species | human, African green, baboon, cynomolgus, rhesus |
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| Isotype | IgG1, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human CD357 (GITR). GITR (glucocorticoid-induced TNF receptor family-regulated gene) is a 25 kD TNF receptor superfamily member (also known as AITR and TNFRSF18). GITR is expressed on activated lymphocytes and is upregulated by T cell receptor engagement. The cytoplasmic domain of GITR is homologous to CD40, 4-1BB and CD27 and has been shown to interact with TRAF 1-3, but not TRAF 5 or 6. GITR signaling has been shown to regulate T cell proliferation and TCR-mediated apoptosis, and to break immunological self-tolerance. GITR binds GITRL and is involved in the development of regulatory T cells and to regulate the activity of Th1 subsets. |
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| Immunogen | n/a |
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| Other Names | Activation-inducible TNFR, AITR, Glucocorticoid-inducible TNFR, TNFRSF18 |
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| Gene, Accession # | Gene ID: 8784 |
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| Catalog # | 311602 |
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| Price | |
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| Order / More Info | GITR Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 18378892 |
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