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產(chǎn)品名稱

Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antibody from ANTIBODIES-ONLINE GmbH

產(chǎn)品貨號(hào)

ABIN1684044

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

50 μg

產(chǎn)品品牌

ANTIBODIES-ONLINE GmbH

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Toll-Like Receptor Adaptor Molecule 1 (TICAM1)
Clone	polyclonal
Host Species	Rabbit
Reactive Species	mouse, rat, human
Isotype	n/a
Format	affinity purified
Size	50 μg
Concentration	n/a
Applications	Western Blotting (WB),Immunohistochemistry (IHC)
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Members of the Toll-like receptor (TLR) family, named for the closely related Toll receptor in Drosophila, play a pivotal role in innate immune responses . TLRs recognize conserved motifs found in various pathogens and mediate defense responses. Triggering of the TLR pathway leads to the activation of NF-kappaB and subsequent regulation of immune and inflammatory genes. The TLRs and members of the IL-1 receptor family share a conserved stretch of approximately 200 amino acids known as the TIR domain. Upon activation, TLRs associate with a number of cytoplasmic adaptor proteins containing TIR domains including MyD88 (myeloid differentiation factor), MAL/TIRAP (MyD88-adaptor-like/TIR-associated protein), TRIF (Toll-receptor-associated activator of interferon), and TRAM (Toll-receptor-associated molecule). This association leads to the recruitment and activation of IRAK1 and IRAK4, which form a complex with TRAF6 to activate TAK1 and IKK. Activation of IKK leads to the degradation of IkappaB that normally maintains NF-kappaB inactivity by sequestering it in the cytoplasm. TRIF (also termed TICAM-1) is a TIR-domain adaptor protein described to activate NF-kappaB, IRF3 and trigger IFN-beta production . Studies using dominant negative forms of TRIF and siRNA targeting TRIF show that TRIF functions downstream of both TLR3 and TLR4 in response to dsRNA and LPS respectively . TRIF recruits TRAF6-TAK1-TAB2 to the receptor complex which leads to NF-kappaB activation . In addition, TRIF can trigger signaling of that lead to the induction of apoptosis . Synonyms: TRIF, PRVTIRB, TICAM-1
Immunogen	Recombinant protein of human TICAM1
Other Names	IIAE6\|MyD88-3\|PRVTIRB\|TICAM-1\|TRIF\|AW046014\|AW547018\|trif
Gene, Accession #	Gene ID: 148022,106759,363328
Catalog #	ABIN1684044
Price
Order / More Info	Toll-Like Receptor Adaptor Molecule 1 (TICAM1) Antibody from ANTIBODIES-ONLINE GmbH
Product Specific References	n/a
產(chǎn)品資料

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