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| Antigenic Specificity | CD312 |
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| Clone | W15101A |
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| Host Species | Rat |
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| Reactive Species | human |
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| Isotype | IgG2a, κ |
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| Format | purified |
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| Size | 100 μg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FC), IHC-F |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Purified anti-human CD312 (EMR2). CD312, also known as Epidermal growth factor module-containing mucin-like receptor 2 (EMR2), is a 90 kD type I protein, a member of the Epidermal Growth Factor-seven transmembrane (EGF-TM7) family. Its extracellular region consists of five tandem EGF-like adhesion domains and a mucin-like stalk domain containing a G-protein proteolytic site, while the C-terminal region consists of a seven-pass transmembrane domain. CD312 is expressed by myeloid cells, dendritic cells, and activated lymphocytes. CD312 contributes to the interaction of macrophages, dendritic cells and activated T cells with B cells; it is involved in neutrophil chemotaxis, degranulation and adhesion, and release of inflammatory cytokines by macrophages. The ligands of CD312 are the glycosaminoglycans (GAG) chondroitin sulphate, and dermatan sulphate. |
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| Immunogen | Recombinant protein fragment containing the first extracellular region of human EMR2 (24-540 a.a.). |
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| Other Names | Epidermal growth factor module-containing mucin-like receptor 2, EMR2, AGRE2, ADGRE2 |
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| Gene, Accession # | Gene ID: 30817 |
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| Catalog # | 373102 |
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| Price | |
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| Order / More Info | CD312 Antibody from BIOLEGEND |
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| Product Specific References | n/a |
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