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| Antigenic Specificity | ZAP-70 |
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| Clone | 1E7.2 |
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| Host Species | Mouse |
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| Reactive Species | human, mouse |
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| Isotype | IgG1, κ |
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| Format | phycoerythrin (PE) conjugate |
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| Size | 25 tests |
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| Concentration | n/a |
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| Applications | Intracellular Staining for Flow Cytometry (ICFC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | PE anti-human/mouse ZAP-70. ZAP-70 is a 70 kD protein tyrosine kinase associated with the zeta chain of the T cell receptor. It is expressed in T cells and NK cells and has been shown to be involved in T cell signaling. Defects in ZAP-70 have been linked to selective T cell defects. The ZAP-70 kinase undergoes multiple phosphorylation events after T cell receptor engagement and interacts with a number of proteins involved in signal transduction. Recently, ZAP-70 has been identified as an important prognostic marker in B-cell chronic lymphocytic leukemia (B-CLL). The 1E7.2 monoclonal antibody recognizes human and mouse ZAP-70 and has been shown to be useful for flow cytometry, Western blotting, and immunoprecipitation. |
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| Immunogen | GST-fusion protein corresponding to residues 282-307 of human ZAP-70 |
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| Other Names | Zeta chain associated protein kinase, SYK related tyrosine kinase |
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| Gene, Accession # | Gene ID: 22637, 7353 |
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| Catalog # | 313403 |
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| Price | |
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| Order / More Info | ZAP-70 Antibody from BIOLEGEND |
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| Product Specific References | PubMed: 19240243 |
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