| 產(chǎn)品詳情 |
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| Antigenic Specificity | IL17 |
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| Clone | 408H6.01 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | purified |
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| Size | 100μg/50μg |
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| Concentration | n/a |
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| Applications | Blocking activity, FACS intracyto, ELISA capture |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | IL-17 (cytotoxic T lymphocyte associated antigen 8) is a CD4+ T cell-derived cytokine that stimulates stromal cells and macrophages to secrete proinflammatory cytokines. To address a possible mechanism by which IL-17 may promote alloreactivity, we examined the influence of IL-17 on the differentiation and function of bone marrow-derived cells propagated in GM-CSF with or without IL-4 to promote dendritic cell (DC) growth. A minor proportion of CD11c+ DC expressed the IL-17R. IL-17 promoted the maturation of DC progenitors, as evidenced by increased cell surface expression of CD11c, costimulatory molecules (CD40, CD80, CD86), and MHC class II Ag, and allostimulatory capacity. IL-17 had a lesser effect on the phenotype and function of more fully differentiated myeloid DC. These findings suggest a role for IL-17 in allogeneic T cell proliferation that may be mediated in part via a maturation-inducing effect on DC. IL-17 appears to be a novel target for therapeutic intervention in allograft rejection. hIL17 stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and G-CSF and PGE2.(Fossiez F et al, 1996 ; J. Exp. Med., 183:2593-2603 ; Fossiez F. et al, 1998 ; Int. Rev. Immunol., 16:541-551 |
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| Immunogen | n/a |
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| Other Names | Interleukin, CTLA-8 (cytotoxic T lymphocyte associated antigen 8) |
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| Gene, Accession # | n/a |
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| Catalog # | DDX0336 |
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| Price | |
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| Order / More Info | IL17 Antibody from DENDRITICS SAS |
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| Product Specific References | n/a |
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