| 產(chǎn)品詳情 |
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| Antigenic Specificity | Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (aa 300-350) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | rat, mouse, human |
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| Isotype | n/a |
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| Format | immunogen affinity purified |
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| Size | 40 μg |
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| Concentration | n/a |
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| Applications | ELISA,Western Blotting (WB),Immunohistochemistry (IHC),Flow Cytometry (FACS) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Parkin, also known as PARKIN2, is a novel protein in Ubl conjugation pathway. Parkin functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. These substrates include CCNE1, SYT11, GPR37, and STUB1, a 22 kDa O-linked glycosylated isoform of SNCAIP and SEPT5. Parkin may play a more general role in the ubiquitin proteasomal pathway by participating in the removal and/or detoxification of abnormally folded or damaged protein. The protein may protect neurons against alpha synuclein toxicity, proteasomal dysfunction, GPR37 accumulation, and kainate-induced excitotoxicity. Defects in PARK2 are a cause of Parkinson disease (PD).Parkin Antibody, pAb, Rabbit is developed in rabbit using a KLH-coupled synthetic peptide within residues 300-350 of human parkin protein (Swiss Prot: O60260). |
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| Immunogen | KLH-coupled synthetic peptide within AA 300-350 of human parkin protein |
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| Other Names | Park|Prkn |
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| Gene, Accession # | Gene ID: 56816 |
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| Catalog # | ABIN1574065 |
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| Price | |
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| Order / More Info | Parkinson Protein 2, E3 Ubiquitin Protein Ligase (PARK2) (aa 300-350) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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