| Description | ABIN134042reacts with the murine CD80 (B7-1) molecule. This member of the Ig superfamily, along with CD86 (B7-2), participates in T cell co- stimulation via interactions with CD28 and CTLA-4. CD80 is constituitively expressed on dendritic cells, monocytes, and peritoneal macrophages and it is inducible on B cells by various means, including activation by LPS, IL-4, and the cross-linking of surface Ig. Expression of CD80 is greatly enhanced on splenic B cells following activation by LPS, with peak expression occurring between 48 and 72 hours. It has been reported that activation of purified B cells with LPS can induce CD80 expression in as few as 18 hours. |
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