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產(chǎn)品名稱

IL17 Antibody from DENDRITICS SAS

產(chǎn)品貨號(hào)

DDX0335

產(chǎn)品價(jià)格

現(xiàn)貨詢價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

100μg/50μg

產(chǎn)品品牌

DENDRITICS SAS

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	IL17
Clone	414A11.03
Host Species	Mouse
Reactive Species	human
Isotype	IgG1
Format	purified
Size	100μg/50μg
Concentration	n/a
Applications	ELISA detecting(with DDX0334 or DDX0336), blocking activity
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	IL-17 (cytotoxic T lymphocyte associated antigen 8) is a CD4+ T cell-derived cytokine that stimulates stromal cells and macrophages to secrete proinflammatory cytokines. To address a possible mechanism by which IL-17 may promote alloreactivity, we examined the influence of IL-17 on the differentiation and function of bone marrow-derived cells propagated in GM-CSF with or without IL-4 to promote dendritic cell (DC) growth. A minor proportion of CD11c+ DC expressed the IL-17R. IL-17 promoted the maturation of DC progenitors, as evidenced by increased cell surface expression of CD11c, costimulatory molecules (CD40, CD80, CD86), and MHC class II Ag, and allostimulatory capacity. IL-17 had a lesser effect on the phenotype and function of more fully differentiated myeloid DC. These findings suggest a role for IL-17 in allogeneic T cell proliferation that may be mediated in part via a maturation-inducing effect on DC. IL-17 appears to be a novel target for therapeutic intervention in allograft rejection. hIL17 stimulate epithelial, endothelial, and fibroblastic cells to secrete cytokines such as IL-6, IL-8, and G-CSF and PGE2.(Fossiez F et al, 1996 ; J. Exp. Med., 183:2593-2603 ; Fossiez F. et al, 1998 ; Int. Rev. Immunol., 16:541-551
Immunogen	n/a
Other Names	Interleukin, CTLA-8 (cytotoxic T lymphocyte associated antigen 8)
Gene, Accession #	n/a
Catalog #	DDX0335
Price
Order / More Info	IL17 Antibody from DENDRITICS SAS
Product Specific References	n/a
產(chǎn)品資料

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