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| Antigenic Specificity | Indoleamine 2,3-Dioxygenase 1 (IDO1) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human |
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| Isotype | n/a |
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| Format | affinity purified |
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| Size | 200 μg |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | INDO/IDO1/indoleamine 2, 3-dioxygenase (IDO) is an IFN-gamma-inducible enzyme that catalyzes the rate-limiting step of tryptophan degradation. IDO is upregulated in many tumors and in dendritic cells in tumor-draining lymph nodes. Elevated tryptophan catabolism in these cells leads to tryptophan starvation of T cells, limiting T cell proliferation and activation. Therefore, IDO is considered an immunosuppresive molecule, and research studies have shown that upregulation of IDO is a mechanism of cancer immune evasion. The gastrointestinal stromal tumor drug, imatinib, was found to act, in part, by reducing IDO expression, resulting in increased CD8+ T cell activation and induction of apoptosis in regulatory T cells. In addition to its enzymatic activity, IDO was recently shown to have signaling capability through an immunoreceptor tyrosine-based inhibitory motif (ITIM) that is phosphorylated by Fyn in response to TGF-beta. This leads to recruitment of SHP-1 and activatation of the noncanonical NF-kappaB pathway.Synonyms: CD107B, IDO, INDO |
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| Immunogen | Recombinant protein of human INDO |
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| Other Names | INDO|ido|indo|IDO|cd107b|IDO1|IDO-1|Ido|Indo |
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| Gene, Accession # | Gene ID: 3620 |
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| Catalog # | ABIN1514241 |
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| Price | |
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| Order / More Info | Indoleamine 2,3-Dioxygenase 1 (IDO1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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