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| Antigenic Specificity | Lysosomal-Associated Membrane Protein 1 (LAMP1) |
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| Clone | H4A3 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG1 |
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| Format | purified |
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| Size | 0.1 mg |
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| Concentration | n/a |
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| Applications | Flow Cytometry (FACS),Immunohistochemistry (IHC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | CD107a, also known as lysosomal-associated membrane protein 1 (LAMP-1), is a heavily glycosylated, type I transmembrane protein that constitutes the major sialoglycoproteins on lysosomal membranes. It is a ligand for galaptin, an S-type lectin present in extracellular matrix, through its recognition of acetyllactosamine oligosaccharide chains, and is a ligand for E-selectin-mediated cell adhesion. CD107a is expressed by granulocytes, T cells, macrophages, dendritic cells, activated platelets, tonsillar epithelium and some tumor cell lines, including U937 and KG1a. It is also a widely expressed intracellular antigen. LAMP-1 may function in protecting the inner surface of the lysosomal membrane by forming a barrier to lysosomal hydrolases. The upregulation of both CD107a and CD107b on the surface of tumor cell lines has been associated with their enhanced metastatic potential, where they may increase adhesion to extracellular matrix and endothelium. |
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| Immunogen | n/a |
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| Other Names | AI196048|CD107a|Lamp-1|LAMPA|LGP120|LEP100 |
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| Gene, Accession # | Gene ID: 3916 |
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| Catalog # | ABIN135831 |
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| Price | |
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| Order / More Info | Lysosomal-Associated Membrane Protein 1 (LAMP1) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | PubMed: 3379044, 2211717, 7685349, 8517882 |
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