| Edit |   |
|---|
| Antigenic Specificity | Interleukin 2 Receptor, alpha (IL2RA) |
|---|
| Clone | PC61-5 |
|---|
| Host Species | Rat |
|---|
| Reactive Species | mouse |
|---|
| Isotype | IgG1 |
|---|
| Format | purified |
|---|
| Size | 0.1 mg |
|---|
| Concentration | n/a |
|---|
| Applications | Functional Studies (Func),Immunohistochemistry (Frozen Sections) (IHC (fro)),Immunoprecipitation (IP),Flow Cytometry (FACS) |
|---|
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
|---|
| Description | CD25 (IL2Ralpha, Tac) is a ligand-binding alpha subunit of interleukin 2 receptor (IL2R). Together with beta and gamma subunit CD25 constitues the high affinity IL2R, whereas CD25 alone serves as the low affinity IL2R. CD25 expression rapidly increases upon T cell activation. The 55 kDa CD25 molecule is enzymatically cleaved and shed from the cell surface as a soluble 45 kDa s-Tac, whose concentration in serum can be used as a marker of T cell activation. Expression of CD25 indicates the neoplastic phenotype of mast cells. CD25+ CD4+ FoxP3+ regulatory cells (Treg cells) play a crucial role in the control of organ-specific autoimmune diseases. |
|---|
| Immunogen | B6.1 CTL cell line |
|---|
| Other Names | CD25|HEM45|IDDM10|IL2R|TCGFR|IL2RAC|IL-2RA|Il2r|Ly-43 |
|---|
| Gene, Accession # | Gene ID: 16184 |
|---|
| Catalog # | ABIN1302435 |
|---|
| Price | |
|---|
| Order / More Info | Interleukin 2 Receptor, alpha (IL2RA) Antibody from ANTIBODIES-ONLINE GmbH |
|---|
| Product Specific References | PubMed: 20037737, 18981144, 9166839, 16000396, 18832672, 17101658 |
|---|