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| Antigenic Specificity | Lysine (K)-Specific Demethylase 5C (KDM5C) (aa 1-156) |
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| Clone | 2E4-E1-G8 |
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| Host Species | Mouse |
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| Reactive Species | human |
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| Isotype | IgG2a |
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| Format | affinity purified |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Western Blotting (WB),Immunocytochemistry (ICC) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | This gene is a member of the SMCY homolog family and encodes a protein with one ARID domain, one JmjC domain, one JmjN domain and two PHD-type zinc fingers. The DNA-binding motifs suggest this protein is involved in the regulation of transcription and chromatin remodeling. Mutations in this gene have been associated with X-linked mental retardation. Alternative splicing results in multiple transcript variants. Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. Participates in transcriptional repression of neuronal genes by recruiting histone deacetylases and REST at neuron-restrictive silencer elements. Subunit structure: Part of two distinct complexes, one containing E2F6, and the other containing REST. Subcellular location: NucleusSequence similarities: Belongs to the JARID1 histone demethylase family. Contains 1 ARID domain. Contains 1 JmjC domain. Contains 1 JmjN domain. Contains 2 PHD-type zinc fingers |
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| Immunogen | Purified recombinant human KDM5C / Jarid1C / SMCX protein fragments expressed in E.coli |
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| Other Names | DXS1272E|JARID1C|MRXJ|MRXSCJ|MRXSJ|SMCX|XE169|Jarid1c|Smcx|mKIAA0234 |
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| Gene, Accession # | Gene ID: 8242 |
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| Catalog # | ABIN488238 |
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| Price | |
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| Order / More Info | Lysine (K)-Specific Demethylase 5C (KDM5C) (aa 1-156) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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