| Description | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI,which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1,as well as regulate the expression of the tumorigenic protein CD44. Mutations in this gene cause rhabdoid tumor predisposition syndrome type 2. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq,May 2012]Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Component of the CREST-BRG1 complex,a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons,transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC repressor complex. Upon calcium influx,RB1 is dephosphorylated by calcineurin,which leads to release of the repressor complex. At the same time,there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism,which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter,and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons,npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A,are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. SMARCA4/BAF190A may promote neural stem cell self-renewal/proliferation by enhancing Notch-dependent proliferative signals,while concurrently making the neural stem cell insensitive to SHH-dependent differentiating cues by similarity. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex,a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Acts as a corepressor of ZEB1 to regulate E-cadherin transcription and is required for induction of epithelial-mesenchymal transition (EMT) by ZEB1. Subunit structure: Component of the CREST-BRG1 complex,at least composed of SMARCA4/BRG1/BAF190A,SS18L1/CREST,HDAC1,RB1 and SP1 By similarity. Interacts with NR3C1,PGR,SMARD1,TOPBP1 and ZMIM2/ZIMP7. Component of the BAF complex,which includes at least actin (ACTB),ARID1A,ARID1B/BAF250,SMARCA2,SMARCA4/BRG1/BAF190A,ACTL6A/BAF53,ACTL6B/BAF53B,SMARCE1/BAF57,SMARCC1/BAF155,SMARCC2/BAF170,SMARCB1/SNF5/INI1,IKFZ1,and one or more of SMARCD1/BAF60A,SMARCD2/BAF60B,or SMARCD3/BAF60C. Interacts directly with IKFZ1 in the BAF complex. In muscle cells,the BAF complex also contains DPF3. Component of the BAF53 complex,at least composed of BAF53A,RUVBL1,SMARCA4/BRG1/BAF190A,and TRRAP,which preferentially acetylates histone H4 (and H2A) within nucleosomes. Component of the WINAC complex,at least composed of SMARCA2,SMARCA4,SMARCB1,SMARCC1,SMARCC2,SMARCD1,SMARCE1,ACTL6A,BAZ1B/WSTF,ARID1A, SUPT16H,CHAF1A and TOP2B. Interacts with (via the bromodomain) with TERT,the interaction regulates Wnt-mediated signaling. Component of neural progenitors-specific chromatin remodeling complex (npBAF complex) composed of at least,ARID1A/BAF250A or ARID1B/BAF250B,SMARCD1/BAF60A,SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,SMARCA4/BRG1/BAF190A,SMARCB1/BAF47,SMARCC1/BAF155,SMARCE1/BAF57,SMARCC2/BAF170,PHF10/BAF45A,ACTL6A/BAF53A and actin. Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least,ARID1A/BAF250A or ARID1B/BAF250B,SMARCD1/BAF60A,SMARCD3/BAF60C, SMARCA2/BRM/BAF190B,SMARCA4/BRG1/BAF190A,SMARCB1/BAF47,SMARCC1/BAF155,SMARCE1/BAF57,SMARCC2/BAF170,DPF1/BAF45B,DPF3/BAF45C,ACTL6B/BAF53B and actin. Interacts with PHF10/BAF45A by similarity. Interacts with MYOG by similarity. Interacts with ZEB1 (via N-terminus). Subcellular location: NucleusSequence similarities: Belongs to the SNF2/RAD54 helicase family. Contains 1 bromo domain. Contains 1 helicase ATP-binding domain. Contains 1 helicase C-terminal domain. Contains 1 HSA domain. Contains 1 QLQ domain. |
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