| Description | The current understanding of the role of amyloid in Alzheimer's disease (AD) has been established by a remarkable congruence of multiple disciplines: neuropathology, biochemistry, molecular biology, and epidemiological genetics. It is known that amyloid beta is derived, by two sequential cleavages, from the receptor-like amyloid precursor protein (APP). The proteases involved are beta-secretase, identified as the novel aspartyl protease BACE, and gamma-secretase, a multimeric complex containing the presenilins (PS1, PS2). BACE1 and BACE2 have been isolated as homologues of BACE. Description: Serum. Synonyms: Polyclonal BACE antibody, Anti-BACE antibody, beta Amyloid Cleaving Enzyme antibody, beta secretase antibody, BACE C-terminus antibody, APP beta-secretase antibody, asp2 antibody, aspartylprotease 2 antibody, b-Secretase antibody, bace antibody, bace1 antibody, beta-secretase antibody, beta-site amyloid precursor protein cleaving enzyme antibody, beta-site app cleaving enzyme antibody. |
|---|