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| Antigenic Specificity | beta-Site APP-Cleaving Enzyme 1 (BACE) (aa 450-500) |
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| Clone | polyclonal |
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| Host Species | Rabbit |
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| Reactive Species | human, mouse, rat |
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| Isotype | n/a |
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| Format | serum |
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| Size | 100 μL |
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| Concentration | n/a |
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| Applications | Immunohistochemistry (IHC),Western Blotting (WB) |
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| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
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| Description | Function: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. SUBCELLULAR LOCATION: Membrane, Single-pass type I membrane protein. Golgi apparatus > trans-Golgi network. Endoplasmic reticulum. Endosome. Cell surface. Cytoplasmic vesicle membrane. Note: Predominantly localized to the later Golgi/trans-Golgi network (TGN) and minimally detectable in the early Golgi compartments. A small portion is also found in the endoplasmic reticulum, endosomes and on the cell surface. Tissue specificity: Expressed at high levels in the brain and pancreas. In the brain, expression is highest in the substantia nigra, locus coruleus and medulla oblongata.Synonyms: Beta-secretase 1, Aspartyl protease 2, ASP2, Asp 2, Beta-site amyloid precursor protein cleaving enzyme 1, Beta-site APP cleaving enzyme 1, Memapsin-2, Membrane-associated aspartic protease 2, BACE |
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| Immunogen | A synthetic peptide from aa region 450-500 of human BACE1 conjugated to an immunogenic carrier protein has been used as the antigen. |
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| Other Names | BACE1|MGC145931|bace2|MGC68881|MGC68482|BACE2|C76936|Bace|ASP2|BACE|HSPC104|zgc:77409 |
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| Gene, Accession # | Gene ID: 23621,23821,29392 |
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| Catalog # | ABIN1841973 |
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| Price | |
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| Order / More Info | beta-Site APP-Cleaving Enzyme 1 (BACE) (aa 450-500) Antibody from ANTIBODIES-ONLINE GmbH |
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| Product Specific References | n/a |
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