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        產(chǎn)品名稱 CD45/PTPRC Antibody from BOSTER BIO
        產(chǎn)品貨號 PB9785
        產(chǎn)品價格 現(xiàn)貨詢價,電話:010-67529703
        產(chǎn)品規(guī)格 100ug (sample available)
        產(chǎn)品品牌 BOSTER BIO
        產(chǎn)品概述
        產(chǎn)品詳情
        Edit&nbsp
        Antigenic SpecificityCD45/PTPRC
        Clonepolyclonal
        Host SpeciesRabbit
        Reactive Specieshuman
        Isotypen/a
        Formatimmunogen affinity purified
        Size100ug (sample available)
        Concentration500ug/ml.
        ApplicationsFlow Cytometry, IF, IHC-P, IHC-F, WB
        Reviews / RatingsIf you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
        DescriptionRabbit IgG polyclonal Picoband? antibody for Receptor-type tyrosine-protein phosphatase C(PTPRC) detection. Tested with WB, IHC-P, IHC-F, IF, FCM in Human. No cross reactivity with other proteins. CD45 (Cluster of Differentiation 45), also known as PTPRC, LCA or CD45R, is an enzyme that, in humans, is encoded by the PTPRC gene. It is a member of the protein tyrosine phosphatase (PTP) family. CD45 is a major high molecular mass leukocyte cell surface molecule which is also an integral membrane protein tyrosine phosphatase. The cytogenetic location of CD45 is 1q31.3-q32.1. This gene is especially a prototype for transmembrane protein-tyrosine phosphatase (PTP). Targeted disruption of the CD45 gene leads to enhanced cytokine and interferon receptor-mediated activation of JAKs and STAT proteins. In vitro, CD45 directly dephosphorylates and binds to JAKs. Functionally, CD45 negatively regulates interleukin-3-mediated cellular proliferation, erythropoietin-dependent hematopoiesis, and antiviral responses in vitro and in vivo. In addition, CD45 has been best studied in T cells, where it determines T cell receptor signaling thresholds. CD45 is moved into or out of the immunological synapse (IS) membrane microdomain depending on the relative influence of interaction with the extracellular galectin lattice or the intracellular actin cytoskeleton. Galectin interaction can be finetuned by varying usage of the heavily Oglycosylated spliced regions and sialylation of Nlinked carbohydrates.
        ImmunogenA synthetic peptide corresponding to a sequence at the C-terminus of human CD45(1214-1254aa EQYQFLYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVK), different from the related mouse sequence by eight amino acids, and from the related rat sequence by ten amino acids.
        Other NamesReceptor-type tyrosine-protein phosphatase C;3.1.3.48;Leukocyte common antigen;L-CA;T200;CD45;PTPRC;CD45;
        Gene, Accession #PTPRC, UniProt: P08575
        Catalog #PB9785
        Price
        Order / More InfoCD45/PTPRC Antibody from BOSTER BIO
        Product Specific Referencesn/a
        產(chǎn)品資料
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