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產(chǎn)品名稱

Neurokinin 1 Receptor/TACR1 Antibody from BOSTER BIO

產(chǎn)品貨號

PB9446

產(chǎn)品價格

現(xiàn)貨詢價，電話：010-67529703

產(chǎn)品規(guī)格

100ug (sample available)

產(chǎn)品品牌

BOSTER BIO

產(chǎn)品概述

產(chǎn)品詳情

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Antigenic Specificity	Neurokinin 1 Receptor/TACR1
Clone	polyclonal
Host Species	Rabbit
Reactive Species	human, rat (predicted: hamster)
Isotype	n/a
Format	immunogen affinity purified
Size	100ug (sample available)
Concentration	500ug/ml.
Applications	WB
Reviews / Ratings	If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY.
Description	Rabbit IgG polyclonal Picoband? antibody for Substance-P receptor(TACR1) detection. Tested with WB in Human;Rat. No cross reactivity with other proteins. The tachykinin receptor 1 (TACR1), also known as neurokinin 1 receptor (NK1R) or substance P receptor (SPR), is a G protein coupled receptor found in the central nervous system and peripheral nervous system. The endogenous ligand for this receptor is Substance P, although it has some affinity for other tachykinins. The protein is the product of the TACR1 gene. Tachykinin receptor 1 consists of 407 amino acid residues, and it has a molecular weight of 58.000. Tachykinin receptor 1, as well as the other tachykinin receptors, is made of seven hydrophobic transmembrane (TM) domains with three extracellular and three intracellular loops, an amino-terminus and a cytoplasmic carboxy-terminus. The loops have functional sites, including two cysteines amino acids for a disulfide bridge, Asp-Arg-Tyr, which is responsible for association with arrestin and, Lys/Arg-Lys/Arg-X-X-Lys/Arg, which interacts with G-proteins.The tachykinin receptor 1 can be found in both the central and peripheral nervous system. It is present in neurons, brainstem, vascular endothelial cells, muscle, gastrointestinal tracts, genitourinary tract, pulmonary tissue, thyroid gland and different types of immune cells. The binding of SP to the tachykinin receptor 1 has been associated with the transmission of stress signals and pain, the contraction of smooth muscles and inflammation. Tachykinin receptor 1 antagonists have also been studied in migraine, emesis and psychiatric disorders. In fact, aprepitant has been proved effective in a number of pathophysiological models of anxiety and depression. Other diseases in which the tachykinin receptor 1 system is involved include asthma, rheumatoid arthritis and gastrointestinal disorders.
Immunogen	A synthetic peptide corresponding to a sequence at the C-terminus of human TACR1 (264-291aa FHIFFLLPYINPDLYLKKFIQQVYLAIM), different from the related mouse sequence by one amino acid, and from the related rat sequence by two amino acids.
Other Names	Substance-P receptor;SPR;NK-1 receptor;NK-1R;Tachykinin receptor 1;TACR1;NK1R, TAC1R;
Gene, Accession #	TACR1, UniProt: P25103
Catalog #	PB9446
Price
Order / More Info	Neurokinin 1 Receptor/TACR1 Antibody from BOSTER BIO
Product Specific References	n/a
產(chǎn)品資料

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