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產(chǎn)品名稱(chēng)

Non CpG-DNA, Rabbit from HYCULT BIOTECH

產(chǎn)品貨號(hào)

HC4042

產(chǎn)品價(jià)格

現(xiàn)貨詢(xún)價(jià)，電話：010-67529703

產(chǎn)品規(guī)格

200 nmol

產(chǎn)品品牌

HYCULT BIOTECH

產(chǎn)品概述

產(chǎn)品詳情

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Product Name	Non CpG-DNA, Rabbit
Description	ODN 2041 is a prototype of non-CpG oligodeoxynucleotides (ODN) that is not able to stimulate rabbit PBMC in vitro. The vertebrate immune system has evolved innate immune defense pattern recognition receptors (PRRs) that detect unmethylated cytosine-phosphate-guanine (CpG) motifs within bacterial DNA. Cellular activation by CpG motifs occurs via the Toll signal pathway. The Toll-like receptor-9 (TLR9, CD289) appears to be a major component of the CpG-DNA receptor, acting by direct binding to CpG-DNA, which triggers the induction of cell signaling pathways including the mitogen activated protein kinase (MAPKs) and NFκB, leading to stimulation of various cells of the immune system. The human TLR9 is expressed in B cells and plasmacytoid dendritic cells (PDC). Mice also express TLR9 in the myeloid compartment. Optimal sequences for activating TLR9 vary among species. Synthetic ODN contain CpG-DNA motifs mimicking the immunostimulatory effects of bacterial DNA and can, therefore, be used as immunoprotective agents, vaccine adjuvants and anti-allergic agents. CpG ODN also affects immune tolerance and autoimmunity. Different classes of CpG ODN are characterized each with distinct effects on the immune response: CpG-A ('D'-type), CpG-B ('K'-type), and CpG-C. This non-CpG is a 24-mer ODN that is not able to modulate stimulate rabbit PBMC in vitro. It has the following sequence: 5'-ctggtctttctggtttttttctgg-3'. Regular letters represent phosphorothioate linkage.
Size	200 nmol
Concentration	Approximately 200 nmol lyophilized, purified 24-mer non-CpG ODN.
Applications	n/a
Other Names	n/a
Gene, Accession, CAS #	n/a
Catalog #	HC4042
Price
Order / More Info	Non CpG-DNA, Rabbit from HYCULT BIOTECH
Product Specific References	n/a
產(chǎn)品資料

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